\u5728 2018 \u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u7ed3\u679c\u51fa\u6765\u540e\uff0c\u6709\u5a92\u4f53\u548c\u5b66\u8005\u8d28\u7591\u8be5\u5956\u9879\u9057\u6f0f\u4e86\u300c\u5728\u8be5\u9886\u57df\u4f5c\u51fa\u540c\u6837\u6770\u51fa\u8d21\u732e\u7684\u300d\u534e\u4eba\u514d\u75ab\u5b66\u5bb6\u3001\u8036\u9c81\u5927\u5b66\u80bf\u7624\u514d\u75ab\u4e2d\u5fc3\u4e3b\u4efb\u9648\u5217\u5e73\u3002 <\/p>\n
\n\u7f8e\u56fd\u514d\u75ab\u5b66\u5bb6\u8a79\u59c6\u65af\u00b7\u827e\u5229\u68ee\u4ee5\u53ca\u65e5\u672c\u514d\u75ab\u5b66\u5bb6\u672c\u5eb6\u4f51\u56e0\u300c\u53d1\u73b0\u8d1f\u6027\u514d\u75ab\u8c03\u8282\u6cbb\u7597\u764c\u75c7\u7684\u7597\u6cd5\u300d\u88ab\u6388\u4e88 2018 \u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u3002\u8fd9\u4e2a\u7ed3\u679c\u51fa\u6765\u540e\uff0c\u6709\u5a92\u4f53\u548c\u5b66\u8005\u8d28\u7591\u8be5\u5956\u9879\u9057\u6f0f\u4e86\u300c\u5728\u8be5\u9886\u57df\u4f5c\u51fa\u540c\u6837\u6770\u51fa\u8d21\u732e\u7684\u300d\u534e\u4eba\u514d\u75ab\u5b66\u5bb6\u3001\u8036\u9c81\u5927\u5b66\u80bf\u7624\u514d\u75ab\u4e2d\u5fc3\u4e3b\u4efb\u9648\u5217\u5e73\u3002<\/p>\n<\/blockquote>\n
\u5317\u4eac\u65f6\u95f4 10 \u6708 1 \u65e5\u4e0b\u5348 5 \u70b9 30 \u5206\uff0c2018 \u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u6b63\u5f0f\u63ed\u6653\u300270 \u5c81\u7684\u7f8e\u56fd\u514d\u75ab\u5b66\u5bb6\u8a79\u59c6\u65af\u00b7\u827e\u5229\u68ee\uff08James P. Allison\uff09\u4ee5\u53ca 76 \u5c81\u7684\u65e5\u672c\u514d\u75ab\u5b66\u5bb6\u672c\u5eb6\u4f51\uff08Tasuku Honjo\uff09\u5171\u4eab\u4e86\u8fd9\u4efd\u6b8a\u8363\u3002\u4ed6\u4eec\u88ab\u6388\u5956\u7684\u7406\u7531\u662f\u300c\u53d1\u73b0\u8d1f\u6027\u514d\u75ab\u8c03\u8282\u6cbb\u7597\u764c\u75c7\u7684\u7597\u6cd5\u300d\uff0c\u540c\u65f6\uff0c\u4ed6\u4eec\u5c06\u83b7\u5f97 900 \u4e07\u745e\u5178\u514b\u6717\u7684\u5956\u91d1\uff08\u7ea6\u5408\u4eba\u6c11\u5e01 695 \u4e07\u5143\uff09\u3002<\/p>\n
\u5176\u4e2d\uff0c\u8a79\u59c6\u65af\u00b7\u827e\u5229\u68ee\u662f\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u58eb\u3002\u4f5c\u4e3a\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u5148\u9a71\uff0c\u827e\u5229\u68ee\u535a\u58eb\u5df2\u7ecf\u628a\u751f\u7406\u548c\u533b\u5b66\u76f8\u5173\u7684\u5956\u9879\u51e0\u4e4e\u62ff\u904d\uff0c\u552f\u4e00\u7f3a\u7684\u5c31\u662f\u8bfa\u8d1d\u5c14\u5956\u3002\u4ed6 2014 \u5e74\u83b7\u751f\u547d\u79d1\u5b66\u7a81\u7834\u5956\u7b49\u5927\u5956\u30022015 \u5e74\uff0c\u4ed6\u56e0\u300c\u53d1\u73b0\u5e76\u53d1\u5c55\u4e86\u4e00\u79cd\u5355\u514b\u9686\u6297\u4f53\u7597\u6cd5\uff0c\u4fc3\u8fdb\u514d\u75ab\u7cfb\u7edf\u5bf9\u6297\u764c\u75c7\u300d\u83b7\u5f97\u62c9\u65af\u514b\u4e34\u5e8a\u533b\u5b66\u5956\u3002\u636e\u4e86\u89e3\uff0c\u4ed6\u5bf9\u514d\u75ab\u6291\u5236\u5206\u5b50\u7684\u53d1\u73b0\u4e00\u65b9\u9762\u62d3\u5c55\u5bf9\u514d\u75ab\u8c03\u63a7\u7684\u7406\u89e3\uff0c\u53e6\u4e00\u65b9\u9762\u4e5f\u6781\u5927\u9769\u65b0\u4e86\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u3002<\/p>\n
\u800c\u672c\u5eb6\u4f51\u662f\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u5916\u7c4d\u9662\u58eb\uff0c\u65e5\u672c\u5b66\u58eb\u9662\u4f1a\u5458\u3002\u672c\u5eb6\u4f51\u6559\u6388\u4e8e 1992 \u5e74\u53d1\u73b0 T \u7ec6\u80de\u6291\u5236\u53d7\u4f53 PD-1\uff0c2013 \u5e74\u4f9d\u6b64\u5f00\u521b\u4e86\u300c\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u300d\u3002\u4e5f\u56e0\u6d3b\u5316\u8bf1\u5bfc\u80de\u82f7\u8131\u6c28\u9176\u7684\u6709\u5173\u7814\u7a76\u4e3e\u4e16\u95fb\u540d\uff0c\u66fe\u83b7\u5f97\u9996\u5c4a\u5510\u5956\u751f\u6280\u533b\u836f\u5956\u7b49\u91cd\u8981\u8363\u8a89\u3002<\/p>\n
\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u516c\u5e03\u540e\uff0c\u5b66\u754c\u6b22\u817e\uff0c\u4f46\u4e5f\u6709\u5a92\u4f53\u548c\u5b66\u8005\u8d28\u7591\u8be5\u5956\u9879\u9057\u6f0f\u4e86\u300c\u5728\u8be5\u9886\u57df\u4f5c\u51fa\u540c\u6837\u6770\u51fa\u8d21\u732e\u7684\u534e\u4eba\u514d\u75ab\u5b66\u5bb6\u300d\u9648\u5217\u5e73\u3002<\/p>\n
\u8bfa\u5956\u770b\u91cd\u300c\u53d1\u73b0\u300d\u800c\u975e\u300c\u6539\u826f\u300d<\/h2>\n
\u6bcf\u5e74\u8bfa\u8d1d\u5c14\u5956\u63ed\u6653\u524d\u5915\uff0c\u4e00\u4efd\u88ab\u8ba4\u4e3a\u6709\u53ef\u80fd\u5728\u5404\u81ea\u9886\u57df\u83b7\u5f97\u8bfa\u8d1d\u5c14\u5956\u7684\u5019\u9009\u4eba\u540d\u5355\u4e5f\u4f1a\u53d1\u5e03\u3002\u8fd9\u4efd\u5168\u7403\u552f\u4e00\u4f7f\u7528\u91cf\u5316\u6570\u636e\u8fdb\u884c\u9884\u6d4b\u7684\u300c\u5f15\u6587\u6842\u51a0\u5956\u300d\u540d\u5355\u6765\u81ea\u5206\u6790\u673a\u6784 Clarivate Analytics\uff0c\u5206\u6790\u5e08\u57fa\u4e8e\u7814\u7a76\u8005\u6240\u53d1\u8868\u7814\u7a76\u6210\u679c\u88ab\u5168\u7403\u540c\u884c\u5f15\u7528\u7684\u9891\u6b21\u548c\u5f15\u6587\u5f71\u54cd\u529b\uff0c\u9074\u9009\u8bfa\u8d1d\u5c14\u5956\u5956\u9879\u6240\u6d89\u53ca\u7684\u751f\u7406\u5b66\u6216\u533b\u5b66\u3001\u7269\u7406\u5b66\u3001\u5316\u5b66\u53ca\u7ecf\u6d4e\u5b66\u9886\u57df\u4e2d\u5168\u7403\u6700\u5177\u5f71\u54cd\u529b\u7684\u9876\u5c16\u7814\u7a76\u4eba\u5458\u3002<\/p>\n
2018 \u5e74\u7684\u5019\u9009\u4eba\u540d\u5355\u5728\u6628\u5929\u53d1\u5e03\uff0c\u88ab\u9009\u4e2d\u7684\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u5019\u9009\u4eba\u5171\u6709\u4e09\u4f4d\u79d1\u5b66\u5bb6\u3002\u5206\u522b\u662f\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821 Napoleone Ferrara\u3001\u65e5\u672c\u4eac\u90fd\u5927\u5b66\u91d1\u4e45\u5b9e\uff08Minoru Kanehisa\uff09\u548c\u6765\u81ea\u7ea6\u7ff0\u65af\u00b7\u970d\u666e\u91d1\u65af\u5927\u5b66\u7684 Solomon H. Snyder\u3002<\/p>\n
Ferrara \u6559\u6388\u88ab\u9009\u4e2d\u7684\u7406\u7531\u662f\u53d1\u73b0\u4e86\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\uff0c\u4ed6\u7684\u5de5\u4f5c\u4fc3\u8fdb\u4e86\u764c\u75c7\u548c\u5176\u4ed6\u75be\u75c5\u4e2d\u7528\u4e8e\u6291\u5236\u8840\u7ba1\u751f\u957f\u7684\u836f\u7269\u7684\u7814\u53d1\u3002\u91d1\u4e45\u5b9e\u6559\u6388\u4e3b\u8981\u56e0\u4e3a\u5bf9\u751f\u7269\u4fe1\u606f\u5b66\u7684\u8d21\u732e\uff0c\u7279\u522b\u662f\u5bf9\u300a\u4eac\u90fd\u57fa\u56e0\u4e0e\u57fa\u56e0\u7ec4\u767e\u79d1\u5168\u4e66\u300b\u4e00\u4e66\u7684\u5b8c\u5584\u4e0e\u53d1\u5c55\u3002\u800c Snyder \u6559\u6388\u9274\u5b9a\u4e86\u8bb8\u591a\u795e\u7ecf\u9012\u8d28\u548c\u7cbe\u795e\u836f\u7269\u7684\u53d7\u4f53\uff0c\u5305\u62ec\u4e0e\u9e26\u7247\u5236\u5242\u76f8\u5173\u7684\u8111\u611f\u53d7\u5668\u3002\u4ed6\u7684\u89c1\u89e3\u5df2\u5e94\u7528\u4e8e\u8bb8\u591a\u5e38\u89c1\u5904\u65b9\u836f\u7684\u5f00\u53d1\uff0c\u4f8b\u5982\u7528\u4e8e\u63a7\u5236\u75bc\u75db\u7684\u5316\u5408\u7269\u3002<\/p>\n
\u81ea 2002 \u5e74\u5f00\u59cb\uff0c\u5df2\u7ecf\u6709 46 \u4f4d\u300c\u5f15\u6587\u6842\u51a0\u5956\u300d\u5f97\u4e3b\u83b7\u5f97\u8bfa\u8d1d\u5c14\u5956\uff0c\u800c\u8fd9\u4e00\u6b21\uff0c\u8fd9\u4efd\u540d\u5355\u5374\u5c11\u89c1\u5730\u65e0\u4e00\u547d\u4e2d\u3002\u5317\u4eac\u5927\u5b66\u533b\u5b66\u4eba\u6587\u7814\u7a76\u9662\u9662\u957f\u5468\u7a0b\u8ba4\u4e3a\uff0c\u5f15\u6587\u6570\u91cf\u591a\u7684\u786e\u53ef\u4ee5\u8bf4\u660e\u4e86\u7814\u7a76\u7ed3\u679c\u7684\u91cd\u8981\uff0c\u4f46\u8fd8\u8981\u8003\u8651\u5230\u7814\u7a76\u7684\u300c\u539f\u521b\u6027\u300d\u3002\u4e00\u822c\u6765\u8bf4\uff0c\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u66f4\u5f3a\u8c03\u300c\u53d1\u73b0\u300d\u3001\u300c\u53d1\u660e\u300d\uff0c\u800c\u975e\u5728\u539f\u672c\u7684\u57fa\u7840\u7814\u7a76\u4e0a\u300c\u6539\u826f\u300d\u3002\u6bd4\u65b9\u8bf4\uff0c\u91d1\u4e45\u5b9e\u6559\u6388\u5bf9\u300a\u4eac\u90fd\u57fa\u56e0\u4e0e\u57fa\u56e0\u7ec4\u767e\u79d1\u5168\u4e66\u300b\u4e00\u4e66\u7684\u5b8c\u5584\u4e0e\u53d1\u5c55\u5c31\u5c5e\u4e8e\u300c\u6539\u826f\u300d\u3002<\/p>\n
\u539f\u521b\u6027\u7814\u7a76\u662f\u521b\u65b0\u800c\u7a7a\u524d\u7684\u3002\u5728\u300c\u53d1\u73b0\u8d1f\u6027\u514d\u75ab\u8c03\u8282\u6cbb\u7597\u764c\u75c7\u7684\u7597\u6cd5\u300d\u8fd9\u6761\u539f\u521b\u7814\u7a76\u4e4b\u8def\u4e0a\uff0c\u8fd8\u6709\u4e00\u679a\u9057\u73e0\u3002<\/p>\n
\u9057\u6f0f\u7684\u540d\u5b57<\/h2>\n
\u5728 2018 \u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u7ed3\u679c\u51fa\u6765\u540e\uff0c\u6709\u5a92\u4f53\u548c\u5b66\u8005\u8d28\u7591\u8be5\u5956\u9879\u9057\u6f0f\u4e86\u300c\u5728\u8be5\u9886\u57df\u4f5c\u51fa\u540c\u6837\u6770\u51fa\u8d21\u732e\u7684\u300d\u534e\u4eba\u514d\u75ab\u5b66\u5bb6\u3001\u8036\u9c81\u5927\u5b66\u80bf\u7624\u514d\u75ab\u4e2d\u5fc3\u4e3b\u4efb\u9648\u5217\u5e73\u3002<\/p>\n
\u827e\u5229\u68ee\u535a\u58eb\u5728\u63a5\u53d7 21 \u4e16\u7eaa\u7ecf\u6d4e\u62a5\u9053\u91c7\u8bbf\u65f6\u8868\u793a\uff0c\u300c\u76ee\u524d\u8bb8\u591a\u533b\u836f\u516c\u53f8\u90fd\u5728\u4e34\u5e8a\u8fdb\u884c\u4e86\u5927\u91cf\u7684\u75c5\u60a3\u6cbb\u7597\u548c\u7814\u7a76\uff0c\u6bd4\u5982 BMS \u548c\u9ed8\u6c99\u4e1c\u90fd\u6709\u81ea\u5df1\u7684\u8ba1\u5212\uff0c\u4e0d\u7ba1\u662f CTLA-4 \u8fd8\u662f PD-1 \u90fd\u662f\u6211\u4eec\u503c\u5f97\u5173\u6ce8\u7684\u70b9\u4f4d\u3002\u300dPD-1 \u53d7\u4f53\u5219\u662f\u7531\u53e6\u4e00\u4f4d\u83b7\u5956\u8005\u672c\u5eb6\u4f51\u6559\u6388\u4e8e 1992 \u5e74\u53d1\u73b0\uff0c\u800c PD-L1 \u914d\u4f53\u5219\u7531\u9648\u5217\u5e73\u6559\u6388\u4e8e 1999 \u5e74\u53d1\u73b0\u3002<\/p>\n
\u827e\u5229\u68ee\u535a\u58eb\u662f\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u7684\u5148\u9a71\u8005\uff0c\u88ab\u8ba4\u4e3a\u662f\u300c\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u300d\u6982\u5ff5\u7684\u63d0\u51fa\u8005\u3002\u5728\u4e0a\u4e16\u7eaa 80 \u5e74\u4ee3\uff0c\u827e\u5229\u68ee\u535a\u58eb\u5728\u514d\u75ab T \u7ec6\u80de\u4e0a\u53d1\u73b0\u4e86\u4e00\u79cd\u88ab\u79f0\u4e3a CTLA-4 \u7684\u86cb\u767d\uff0c\u5b83\u4f1a\u5e2e\u52a9\u80bf\u7624\u7ec6\u80de\u300c\u9003\u79bb\u300dT \u7ec6\u80de\u7684\u653b\u51fb\u3002<\/p>\n
PD-1 \u662f CTLA-4 \u7684\u300c\u540e\u8d77\u4e4b\u79c0\u300d\uff0c\u7531\u672c\u5eb6\u4f51\u6559\u6388\u5728 1992 \u5e74\u53d1\u73b0\u3002\u4f46\u6700\u521d\uff0c\u8fd9\u4e00\u53d1\u73b0\u5e76\u6ca1\u6709\u4e3a\u80bf\u7624\u514d\u75ab\u5e26\u6765\u6ce2\u6f9c\uff0cPD-1 \u8fd9\u79cd\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53\u5728\u957f\u8fbe 7 \u5e74\u65f6\u95f4\u91cc\u6ca1\u6709\u88ab\u5f15\u8d77\u91cd\u89c6\u3002\u76f4\u5230 1999 \u5e74\uff0c\u672c\u5eb6\u4f51\u6559\u6388\u610f\u5916\u53d1\u73b0\uff0c\u6572\u9664 PD-1 \u7684\u5c0f\u9f20\u90fd\u51fa\u73b0\u4e86\u660e\u663e\u7684\u5173\u8282\u708e\u3002<\/p>\n
\u540c\u5e74\uff0c\u5728\u7f8e\u56fd\u6885\u5965\u533b\u5b66\u4e2d\u5fc3\u5de5\u4f5c\u7684\u9648\u5217\u5e73\u6559\u6388\u72ec\u7acb\u53d1\u73b0\u4e86 B7-H1\uff08\u4e5f\u5c31\u662f\u73b0\u5728\u4e3a\u4eba\u6240\u719f\u77e5\u7684 PD-L1\uff09\u53ef\u4ee5\u6291\u5236\u514d\u75ab\u53cd\u5e94\u3002\u90a3\u4e2a\u65f6\u5019\u9648\u5217\u5e73\u6559\u6388\u8fd8\u4e0d\u77e5\u9053\u81ea\u5df1\u53d1\u73b0\u7684 B7-H1 \u548c\u672c\u5eb6\u4f51\u6559\u6388\u53d1\u73b0\u7684 PD-1 \u662f\u914d\u4f53\u548c\u53d7\u4f53\u7684\u5173\u7cfb\u3002\u540e\u6765\u672c\u5eb6\u4f51\u6559\u6388\u548c\u6765\u81ea\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u7684 Gordon Freeman \u8bc1\u5b9e\u4e86 PD-L1\uff08\u5373 B7-H1\uff09\u80fd\u548c PD-1 \u7ed3\u5408\uff0c\u4ece\u800c\u6291\u5236 T \u7ec6\u80de\u7684\u7e41\u6b96\u548c\u7ec6\u80de\u56e0\u5b50\u7684\u5206\u6ccc\u3002<\/p>\n
2002 \u5e74\uff0c\u9648\u5217\u5e73\u6559\u6388\u5c06 B7-H1 \u5e94\u7528\u5728\u80bf\u7624\u514d\u75ab\u65b9\u5411\u3002\u4ed6\u53d1\u73b0 B7-H1 \u5145\u5f53\u4e86\u80bf\u7624\u7ec6\u80de\u7684\u300c\u76fe\u724c\u300d\uff0c\u53ef\u4ee5\u514d\u4e8e T \u7ec6\u80de\u7684\u653b\u51fb\u30022006 \u5e74\uff0c\u9648\u5217\u5e73\u6559\u6388\u7ec4\u7ec7\u5f00\u5c55\u4e86 anti-PD1\/PD-L1 \u6297\u4f53\u9014\u5f84\u7684\u9996\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u3002\u6240\u4ee5\uff0c\u5b66\u672f\u754c\u9010\u6e10\u8ba4\u540c\uff0c\u672c\u5eb6\u4f51\u6559\u6388\u53d1\u73b0\u7684\u662f PD-1\uff0c\u9648\u5217\u5e73\u6559\u6388\u53d1\u73b0\u7684\u662f PD-L1\uff08\u5373 B7-H7\uff09\uff0c\u4e24\u4eba\u662f\u72ec\u7acb\u53d1\u73b0\u7684\u3002<\/p>\n
\u9648\u5217\u5e73\u6559\u6388\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u53d1\u73b0 PD-1\/PD-L1 \u4fe1\u53f7\u901a\u8def\uff0c2013 \u5e74\u88ab\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u8bc4\u4e3a\u5f53\u5e74\u6700\u4e3a\u91cd\u8981\u7684\u79d1\u5b66\u7a81\u7834\u3002<\/p>\n
\u636e\u4e86\u89e3\uff0c\u300c\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u300d\u662f\u901a\u8fc7\u4eba\u4f53\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\u6d88\u706d\u764c\u7ec6\u80de\u3002\u800c\u6291\u5236 PD-1 \u5219\u80fd\u591f\u6d3b\u5316 T \u7ec6\u80de\uff0c\u523a\u6fc0\u751f\u7269\u4f53\u5185\u514d\u75ab\u529f\u80fd\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u764c\u75c7\u7684\u76ee\u7684\u3002\u76ee\u524d\uff0c\u6297 PD-1 \u764c\u75c7\u514d\u75ab\u6cbb\u7597\u5df2\u5728\u7f8e\u56fd\uff0c\u6b27\u76df\u548c\u65e5\u672c\u83b7\u5f97\u6279\u51c6\u3002\u8fd9\u79cd\u6cbb\u7597\u9769\u65b0\u4e86\u4f20\u7edf\u7684\u764c\u75c7\u6cbb\u7597\uff0c\u5e76\u88ab\u55bb\u4e3a\u611f\u67d3\u6027\u75be\u75c5\u4e2d\u7684\u9752\u9709\u7d20\u3002<\/p>\n
\u5f88\u9057\u61be\uff0c\u867d\u7136\u8bfa\u5956\u59cb\u7ec8\u65e0\u6cd5\u5199\u4e0a\u6240\u6709\u82f1\u96c4\u7684\u540d\u5b57\uff0c\u4f46\u79d1\u5b66\u5bb6\u4eec\u4e3a\u6218\u80dc\u300c\u4f17\u75c5\u4e4b\u738b\u300d\u764c\u75c7\u6240\u505a\u7684\u5168\u90e8\u52aa\u529b\uff0c\u90fd\u503c\u5f97\u4e3a\u4eba\u4eec\u6240\u94ed\u8bb0\u3002<\/p>\n
\u53c2\u8003\uff1a<\/strong><\/p>\n
\u8bfa\u5956\u5b98\u7f51<\/p>\n
\uff08http:\/\/t.cn\/RVcxf6V\uff09<\/p>\n
Cancer immunologists scoop medicine Nobel Prize<\/p>\n
\uff08http:\/\/t.cn\/Ehwse9X\uff09<\/p>\n
Clarivate Analytics Reveals Annual Forecast of Future Nobel Prize Recipients<\/p>\n
\uff08http:\/\/t.cn\/EhAvTxb\uff09<\/p>\n
Should the Nobel Prizes be cancelled?<\/p>\n
\uff08http:\/\/t.cn\/EhAPANJ\uff09<\/p>\n
*\u672c\u6587\u4f5c\u8005biu\uff0c\u7531\u65b0\u82bdNewSeed\u5408\u4f5c\u4f19\u4f34\u6781\u5ba2\u516c\u56ed\u6388\u6743\u53d1\u5e03\uff0c\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u539f\u51fa\u5904\u3002\u5982\u5185\u5bb9\u3001\u56fe\u7247\u6709\u4efb\u4f55\u7248\u6743\u95ee\u9898\uff0c\u8bf7\u8054\u7cfb\u65b0\u82bdNewSeed\u5904\u7406\u3002 \u5206\u4eab\u957f\u5fae\u535a \u5206\u4eab\u5230\u5fae\u4fe1 \u8bfa\u8d1d\u5c14\u5956 \u80bf\u7624\u514d\u75ab \u9648\u5217\u5e73 <\/p>\n
\u76f8\u5173\u9886\u57df\u7684\u6295\u8d44\u4eba<\/h4>\n
\n
- \n
\u738b\u5b50\u8c0b \u5f18\u6656\u57fa\u91d1<\/h3>\n
\u5f18\u6656\u57fa\u91d1<\/p>\n
\u9ad8\u7ea7\u6295\u8d44\u7ecf\u7406 \u673a\u6784\u6295\u8d44\u4eba\u8ba4\u8bc1<\/span><\/p>\n
\u7ea6\u8c08 \u6295\u8d44\u9886\u57df\uff1a \u533b\u836f \u533b\u7597\u5668\u68b0 \u79d1\u6280\u533b\u7597 \u533b\u7597\u670d\u52a1 \u5176\u4ed6 <\/li>\n<\/ul>\n
<\/span><\/h3>\n
\n
- \n
\u65b0\u82bd\u5feb\u8baf|\u4e13\u6ce8\u4e8e\u80bf\u7624\u514d\u75ab\u7597\u6cd5\uff0cApexigen\u83b7\u5f97B\u8f6e\u548cC\u8f6e\u5171\u8ba17300\u4e07\u7f8e\u5143\u7684\u878d\u8d44<\/h3>\n
quinn<\/span> \u00b7<\/span> 2018\/8\/13 11:28:00<\/span> Apexigen \u533b\u7597 \u878d\u8d44 <\/li>\n
- \n
\u65b0\u82bd\u5feb\u8baf|\u805a\u7126\u4e8e\u80bf\u7624\u514d\u75ab\uff0c\u4ec1\u4e1c\u533b\u5b66\u83b77500\u4e07\u4eba\u6c11\u5e01A\u8f6e\u878d\u8d44<\/h3>\n
quinn<\/span> \u00b7<\/span> 2018\/8\/1 10:05:00<\/span> \u4ec1\u4e1c\u533b\u5b66 \u80bf\u7624 \u878d\u8d44 <\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"
\u5728 2018 \u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u7ed3\u679c\u51fa\u6765\u540e\uff0c\u6709\u5a92\u4f53\u548c\u5b66\u8005\u8d28\u7591\u8be5\u5956\u9879\u9057\u6f0f\u4e86\u300c\u5728\u8be5\u9886\u57df\u4f5c\u51fa\u540c\u6837\u6770\u51fa\u8d21\u732e\u7684\u300d\u534e\u4eba…<\/p>\n","protected":false},"author":141,"featured_media":3815,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[376],"class_list":["post-3814","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tech","tag-biu"],"_links":{"self":[{"href":"http:\/\/www.yuntou8.com\/index.php?rest_route=\/wp\/v2\/posts\/3814","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.yuntou8.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.yuntou8.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.yuntou8.com\/index.php?rest_route=\/wp\/v2\/users\/141"}],"replies":[{"embeddable":true,"href":"http:\/\/www.yuntou8.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3814"}],"version-history":[{"count":0,"href":"http:\/\/www.yuntou8.com\/index.php?rest_route=\/wp\/v2\/posts\/3814\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.yuntou8.com\/index.php?rest_route=\/wp\/v2\/media\/3815"}],"wp:attachment":[{"href":"http:\/\/www.yuntou8.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3814"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.yuntou8.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3814"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.yuntou8.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3814"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}